Episode #312: Cortisol Overview and Dieting's Effects
Sep 20, 2024
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Dr. Feigenbaum, a leading expert on cortisol and dieting, dives deep into the complex relationship between cortisol levels and weight management. He explains how cortisol functions in the body, particularly during stress and dieting. The conversation highlights the effects of fasting and calorie deficits on cortisol, and how these fluctuations can impact weight loss efforts. Dr. Feigenbaum also discusses the link between cortisol and abdominal fat, revealing insights into pre-surgery cortisol levels and their implications for weight regain after metabolic surgery.
Cortisol, a critical hormone produced in the adrenal gland, regulates stress responses and energy management during calorie deficits.
The relationship between cortisol levels and weight management outcomes is complex, showing individual variances rather than a direct correlation.
Deep dives
Understanding Cortisol and Its Functions
Cortisol is a steroid hormone produced primarily in the adrenal gland, and it plays a critical role in the body’s response to stress. It aids in various functions, including regulating blood pressure, inflammation, and immune system activity. The adrenal gland consists of distinct layers, with cortisol being produced in the zona fasciculata, which is essential for managing energy, particularly during stressful situations. Increased cortisol levels provide energy by signaling the liver, muscles, and fat tissues to release stored carbohydrates, break down fats, and mobilize proteins for use.
Cortisol's Response to Dietary Changes
When the body is in a calorie deficit, it perceives this as a form of stress, which can lead to increased cortisol levels. Research has shown that while fasting consistently raises cortisol, the relationship between energy deficits and cortisol increase is less clear-cut. Although initial cortisol spikes can occur with dietary restrictions, these levels tend to normalize over time, regardless of the severity of the calorie reduction. Interestingly, elevated cortisol levels can lead to negative health outcomes such as increased abdominal obesity, particularly in those with significant weight changes.
Cortisol's Impact on Weight Management
Cortisol levels demonstrate a complex relationship with body mass index (BMI) and weight management outcomes. Individuals classified as underweight or obese generally exhibit higher cortisol levels, but higher BMI does not necessarily correlate with better health outcomes. Evidence suggests that pre-surgery cortisol levels might predict post-operative weight regain in patients undergoing bariatric surgery, while lifestyle-based weight loss efforts do not show a consistent relationship with cortisol levels. Overall, while excess and inadequate dietary intake elevate cortisol, successful weight management appears to rely more on individual variances than on cortisol level stabilization.
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