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First Principles with Christian Keil
#15: The First Principles Approach to Not Dying | Bryan Johnson
Jun 19, 2024
Bryan Johnson, founder of a secular religious movement, spends $2m/year to avoid death. He discusses innovative approaches to longevity, including quantifying death with 'Die Scores,' measuring biological age, gene therapy, brain interfaces, and identifying effective longevity levers. Bryan emphasizes the importance of scientific rigor and assembling a team of misfits to tackle aging.
46:57
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Quick takeaways
- Transition from conventional to zeroth principle thinking challenges existing paradigms and sparks innovation.
- Proactive approach to aging through targeted therapies and gene interventions emphasizes longevity and healthspan.
Deep dives
Creating a Framework for First Principles Thinking and Zeroth Principle Thinking
The speaker embarked on a journey to develop a philosophical structure that supports the future of humanity by engaging in first principles thinking. Through a series of thought experiments and discussions with peers, the concept of zeroth principle thinking emerged as a new approach to envisioning radical change. This transition from conventional to zeroth principle thinking aims to challenge existing paradigms and spark innovation beyond traditional boundaries.
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