Exploring the Don't Die Framework and Biological Aging

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Episode 15: Bryan Johnson spends $2m/year to not die. But this is more than just a health craze — it’s the birth of a new, secular religious movement. Here’s what Bryan believes.

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(00:00) - Introduction
(01:13) - Zeroth Principles Thinking: Going Beyond First Principles
(04:05) - The Journey to "Don't Die": Bryan's Thought Experiments and Realizations
(07:28) - Is "Don't Die" a Religion? Examining the Parallels
(10:40) - Bryan's Roles in "Don't Die": Philosopher, Embodiment, Message Bearer
(13:05) - Sponsor Break
(14:08) - Quantifying Death: Introducing "Die Scores" for Behaviors and Choices
(17:03) - What is Death and What is Aging? A First Principles Perspective
(19:40) - Measuring Biological Age: Organ by Organ Analysis of Bryan's Body
(23:48) - The Penis as a Marker of Overall Health and Vitality
(26:33) - Epigenetic Clocks and the Pace of Aging Calculated Tests
(30:18) - Bryan's Experience with Follistatin Gene Therapy
(32:25) - Kernel: Building a Mass Market Brain Interface with Time-Domain FNIRS
(36:48) - The Power Law Interventions: Identifying the Most Effective Longevity Levers
(39:22) - Assembling a Team of Scientific Misfits to Tackle Aging
(41:05) - Dreaming Up Ideas: Bryan's Nocturnal Creativity
(42:15) - Telomeres and the Risks of Telomerase Gene Therapy
(44:38) - Reflections on the Challenges of Commercializing Deep Tech
(46:29) - Conclusion: Banding Together to Build an Amazing Future

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Links:

• Christian Keil – https://twitter.com/pronounced_kyle
• Bryan Johnson - https://x.com/bryan_johnson
• Bryan Johnson Personal Website - https://www.bryanjohnson.com/
• Blueprint - https://blueprint.bryanjohnson.com/

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Production and marketing by The Deep View (https://thedeepview.co). For inquiries about sponsoring the podcast, email team@firstprinciples.fm

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