
First Principles with Christian Keil
On First Principles, Christian Keil, Host and Chief of Staff at Astranis, dives into the heart of innovation, making the complex world of deep tech startups approachable without needing a PhD.
Latest episodes

Nov 24, 2024 • 52min
Is It Possible to Build SAFE Nuclear Reactors? | Matt Loszak, Aalo Atomics
Matt Loszak, co-founder and CEO of Allo Atomics, is on a mission to revolutionize nuclear energy with melt-down proof reactors. He dives into the groundbreaking uranium zirconium hydride fuel which enhances reactor safety through its unique self-cooling properties. The discussion covers innovative reactor designs, the advantages of modular systems, and how these advancements could reshape the energy landscape. Loszak also contrasts the challenges of fusion with the practicality of fission, advocating for a safer, more efficient nuclear future.

Sep 2, 2024 • 49min
The World's Safest Humanoid Robots
Discover the fascinating world of humanoid robots designed for safety and efficiency. Learn how 1X Technologies is paving the way for robots to enter consumer homes next year. Explore the innovative design principles that ensure safe interaction through low-speed motors and advanced safety mechanisms. Delve into the intricacies of training these robots with limited data and the balance between structured and unstructured development methods. Gain insights into teleoperation advancements and the future challenges of scaling up humanoid robot deployment.

Aug 29, 2024 • 55min
The World's Quietest Electric Engine | Ian Villa, Whisper Aero
Engines are loud — Whisper Aero is changing that.

Aug 7, 2024 • 1h 1min
How To Build a 1-Terawatt, 600,000 Amp Pulsed Power Generator | JC Btaiche, Fuse Energy
Season 2, Episode 1: JC Btaiche, Fuse Energy======Links:ElectroBOOM: https://www.youtube.com/watch?v=_PcBgym21TAFuse's Paper in Nature: https://www.nature.com/articles/s41598-024-67774-4Fuse — https://www.f.energyPeople:JC Btaiche — https://x.com/JCBtaiche10Christian Keil — https://x.com/pronounced_kyle

Jun 19, 2024 • 47min
#15: The First Principles Approach to Not Dying | Bryan Johnson
Bryan Johnson, founder of a secular religious movement, spends $2m/year to avoid death. He discusses innovative approaches to longevity, including quantifying death with 'Die Scores,' measuring biological age, gene therapy, brain interfaces, and identifying effective longevity levers. Bryan emphasizes the importance of scientific rigor and assembling a team of misfits to tackle aging.

6 snips
Jun 13, 2024 • 1h 14min
#14: Quantum Computing Isn’t Dead Yet | César Rodríguez, Commutator Studios
César Rodríguez, a quantum computing visionary, discusses the potential of quantum computing yet to be unlocked. Topics include quantum mechanics, quantum gates, quantum supremacy, qubit scaling, error correction, probabilistic computing, and the future of quantum computing revolution.

Jun 6, 2024 • 56min
#13: Simon Pickup - Exploring Use Cases for Hydrogen Fuel | Teralta
Simon Pickup, CEO of Teralta, discusses hydrogen fuel production, storage challenges, and use cases. Topics include clean vs dirty production, transportation applications, financing projects, and common misconceptions about hydrogen. The podcast dives into off-take agreements, accelerating adoption with technology, and the potential of hydrogen in various industries.

10 snips
May 29, 2024 • 1h 7min
#12: Deep Prasad - How to Build a Physics-Fluent AI System
Deep Prasad, an expert in building AI systems for understanding physics, discusses the challenges of AI in physics, materials discovery, and the potential of advanced physics AI for space exploration. Topics include optimizing materials at the atomic level, the complexities of perovskites, expanding into geophysics, launching satellites with SpaceX, and the future 'Yug-Cyberia' civilization enabled by advanced physics AI.

May 22, 2024 • 1h 12min
#11: Aleh Kandrashou & Aleksandr Gampel - Building the Factory that Builds the Homes
Today’s episode is brought to you by Strata. Elevate your enterprise identity with Strata today. Go to https://strata.io/firstprinciples to learn more!======Episode 11: Cuby is creating the Factory that builds the Homes. These factories can generate 1 home per day, but instead of building the homes themselves, Cuby works with local operators who produce and sell the pre-fabricated homes.======(00:00) - Intro(00:28) - Cuby is Building the Factory That Builds Homes(02:11) - Cuby Builds Better Tools for Home Builders(04:39) - How Cuby's Mobile Micro Factories Enable Home Building with Less Skilled Labor(07:06) - The Performance and Cost Advantages of Cuby's Approach(09:54) - Who Normally Builds Homes - Developers, General Contractors, Subcontractors(13:02) - How Cuby Replaces Skilled Labor with Unskilled Labor(16:19) - Cuby's 3-Tiered Master Plan - From White Label Factories to an Iconic Brand(19:56) - The Challenges of Explaining Cuby's Full Stack Approach(21:14) - People - Who Works at Cuby's Job Sites vs. Traditional Construction(25:48) - Process - Enabling Home Customization Within a Standardized System(29:07) - How Software Guides Workers Through Simple, Repeatable Operations(32:15) - Dynamically Generating Instructions and Tasks Based on the Home Design(35:44) - Push vs. Pull and Just-in-Time Manufacturing Across Many Simultaneous Homes(38:39) - The Advantages of Localized Manufacturing and Familiar Materials(40:52) - Designing the Ideal Factory Process and Iterating Based on Real World Learnings(44:28) - Using Data and Metrics to Constantly Improve Efficiency(46:11) - Technology - Building Proprietary Machines and Tooling for Key Processes(49:36) - Making vs. Buying Components Based on Customization, Cost and Warranty Factors(52:17) - Why Cuby Believes 3D Printing is Not Yet the Solution for Home Building(54:59) - Cuby's Technical Readiness Level and Roadmap(57:06) - Expanding from Single Family Homes to Other Building Types(59:13) - Strong Traction and Demand from the Housing Ecosystem(01:02:19) - Scaling Production with a Mass Manufacturing "Papa Factory"(01:04:10) - The Independent Nature of Each Factory Enables Efficient Scaling(01:05:53) - Fundraising to Fuel Expansion and Transition to Debt Financing(01:08:34) - The Climate Tech Angle and Economics as Sustainability Driver(01:09:50) - Key Milestones for the Next Fundraise(01:10:37) - Conclusion - Revolutionizing Home Building from the Ground Up======Links:Christian Keil – https://twitter.com/pronounced_kyleAleh Kandrashou - https://x.com/AKandrashouAleksandr Gampel - https://x.com/agampel1Cuby - https://www.cubytechnologies.com/======Production and marketing by The Deep View (https://thedeepview.co). For inquiries about sponsoring the podcast, email team@firstprinciples.fm======Checkout the video version here → http://tinyurl.com/4fh497n9🔔 Follow to stay updated with new uploads

May 15, 2024 • 1h 7min
#10: Sam D'Amico - How to Boil Water in 40 Seconds (and Revolutionize the Grid)
Sam D'Amico discusses Impulse Labs' plan to revolutionize the grid with high-performance home appliances. Topics include the performance difference of Impulse's stoves, the use of batteries for high power, and the potential for battery-powered appliances to transform the grid.
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