Something You Should Know

The New Science of Living Longer & How to Master the Fear of Being Judged - SYSK Choice

Dec 20, 2025
Colleen Murphy, a professor at Princeton specializing in aging research, discusses groundbreaking findings on extending healthy lifespan, including intriguing experiments with worms that reveal aging pathways. Michael Gervais, a high-performance psychologist, explores the universal fear of judgment, explaining its evolutionary roots and how it holds many back from pursuing opportunities. They both provide practical strategies for overcoming these fears and enhancing life quality, emphasizing purpose-driven actions and mindfulness.
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INSIGHT

Aging Is Systemic Damage, Not Just Time

  • Aging reflects cumulative damage and reduced repair across cells and tissues.
  • Colleen T. Murphy explains that aging is multi-level breakdown, not just time passing.
ANECDOTE

One Mutation Makes Worms Act Young

  • A single DAF-2 mutation doubled a worm's lifespan and preserved youth-like function.
  • Murphy's lab used that mutant to show extended memory and delayed oocyte aging in worms.
INSIGHT

Worm Discoveries Translate To Mice

  • Findings in worms scaled to mice: a protein improved cognition in old mice.
  • Murphy highlights conserved biology that could guide human memory treatments.
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