
Huberman Lab Essentials: Breathing for Mental & Physical Health & Performance | Dr. Jack Feldman
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Nov 13, 2025 Dr. Jack Feldman, a Distinguished Professor of Neurobiology at UCLA, joins to unravel the fascinating mechanics of breathing. He explores how our breath influences mental states, including anxiety reduction and emotional resilience. Feldman shares practical techniques like box breathing and highlights the importance of the diaphragm in respiration. He also discusses the cognitive benefits of magnesium L-threonate and its potential for improving mental clarity. Tune in for a deep dive into how mastering breath can enhance overall well-being.
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Brain Rhythm That Starts Every Breath
- The pre-Bötzinger complex in the brainstem initiates every breath by activating motor neurons to the diaphragm and intercostals.
- Inspiration ends when that neuronal burst stops and passive recoil drives exhalation.
Separate Circuit For Active Expiration
- A separate oscillator around the facial nucleus drives active expiration during exertion or forced exhalation.
- Mammals uniquely evolved a diaphragm, enabling efficient inspiration and high lung surface area.
Diaphragm Enables Massive Lung Surface Area
- Mammals pack ~400–500 million alveoli to create a huge surface area for gas exchange within a small chest.
- The diaphragm's mechanical advantage expands that membrane with minimal effort to sustain oxygen delivery.

