Two Onc Docs Hodgkin Lymphoma 2025 UPDATE
Nov 24, 2025
The podcast dives into the latest updates on Hodgkin Lymphoma, covering critical aspects like its pathology and staging. It highlights the differences between classical and nodular lymphocyte-predominant types and discusses the significance of Deauville PET scoring in treatment evaluation. There’s a thorough exploration of chemotherapy regimens, including the potential of immunotherapy for advanced stages. Additionally, the episode addresses long-term survivorship issues, from late effects to fertility and cardiopulmonary concerns.
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Young Adults Are The Primary Population
- Hodgkin lymphoma peaks in young adults (20–24) and has high cure rates around 85–90% across stages.
- Long-term toxicities and fertility considerations are crucial when treating this AYA population.
Always Use Excisional Biopsy For Diagnosis
- Use an excisional biopsy to preserve architecture and identify Reed–Sternberg or popcorn cells.
- Differentiate classical (CD15+, CD30+) from nodular lymphocyte-predominant (CD20+, CD15/30-) to guide therapy.
IPS Score Predicts Survival
- The IPS prognostic score uses SAW MEAL mnemonic to predict 5-year OS differences from ~80% to ~60%.
- Higher IPS correlates with worse survival but outcomes are improving with new therapies.