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Cholesterol's Dual Nature
- Cholesterol is essential for cell function, but high levels can be detrimental.
- LDL receptors regulate cholesterol uptake, maintaining a balance.
Cholesterol Regulation
- Cholesterol levels are regulated by a negative feedback loop involving the LDL receptor, primarily in the liver.
- This system maintains low plasma LDL levels while providing enough cholesterol to cells.
LDL Receptor and Risk
- Genetic conditions linked to high LDL cholesterol involve the LDL receptor.
- Drugs and dietary changes that lower LDL act by upregulating LDL receptor activity.