Melatonin: mechanisms of action and it’s amazing role beyond sleep with Dr. Adrian Lopresti and Dr. Deanna Minich
Feb 26, 2024
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Learn about the diverse aspects of melatonin beyond sleep - from gut health to mitochondria. Discover the six pivotal roles melatonin plays, natural methods to boost production, and dosage recommendations. Explore its impact on circadian rhythms, chronic diseases, and anti-aging benefits.
Melatonin plays a pivotal role in regulating circadian rhythms and has diverse systemic impacts beyond sleep.
The antioxidant and anti-inflammatory properties of melatonin offer potential anti-aging benefits and support healthy cellular function.
Personalized approaches to optimizing melatonin levels through lifestyle factors and supplementation can enhance its therapeutic effectiveness.
Deep dives
Melatonin: An Overview of Its Origins and Role in the Body
Melatonin, known as the darkness hormone, is an endolamine producing essential neurotransmitter-like effects. It is synthesized in the pineal gland in response to darkness and is distributed systemically to regulate circadian rhythms. Apart from the pineal gland, melatonin is also produced in various body tissues, such as mitochondria, influencing processes like gastrointestinal motility and immune system function.
Melatonin's Role Beyond Sleep: Antioxidant and Anti-inflammatory Properties
Melatonin serves as a powerful antioxidant, combating free radicals up to 10 times more effectively than other antioxidants like vitamin C. Its anti-inflammatory properties, particularly highlighted during the pandemic, aid in quelling cytokine storms. The molecule's multifaceted functions extend to nerve growth factor effects, mitochondrial regulation, and circadian rhythm modulation.
Melatonin in Mitochondria and Potential Anti-Aging Properties
Melatonin's presence in mitochondria points to its evolutionary role in protecting cells from oxidative stress by modulating metabolism and regulating reactive oxygen species. This ancient molecule, with its antioxidant and anti-inflammatory effects, is increasingly recognized for its potential anti-aging properties and ability to promote healthy cellular function.
Factors Influencing Melatonin Production and Supplementation
External factors like exposure to artificial light and dietary choices influence melatonin production. Ensuring adequate darkness and a diet rich in antioxidants and proteins supports natural melatonin levels. When considering supplementation, a personalized approach, taking into account genetic metabolism differences, timing, and dosage is crucial for optimal efficacy.
Considerations for Melatonin Supplementation and Personalized Usage
Melatonin supplements should be taken 40-60 minutes before bedtime, with considerations for metabolism rates and individual responses. While synthetic melatonin is widely available, exploring plant-based melatonin sources may offer superior antioxidant and anti-inflammatory benefits. Tailoring usage based on age, conditions, and genetic factors optimizes its therapeutic potential.
Dr. Deanna Minich provides a comprehensive exploration of the diverse aspects of melatonin for a deeper understanding on the mechanisms and benefits of this sleep-associated neurotransmitter. The discussion, hosted by fx Ambassador Dr. Adrian Lopresti, covers the different types of melatonin in the body, shedding light on its production sites and presence throughout most body systems.
Furthermore, it delves into the connection between melatonin and the gut, melatonin's impact on mitochondria, and a detailed breakdown of the six pivotal roles that melatonin plays. They discuss the variety of health conditions melatonin can support, and outline natural methods to boost melatonin production - starting with optimising exposure to light, dietary recommendations and the power of plant sourced melatonin.
Listeners will gain insights into the amount of melatonin produced endogenously across various life stages and, most importantly, the podcast discusses safety, varying regulation, and offers crucial dosage recommendations supported by evidence.
Find today's transcript and show notes here: https://www.fxmedicine.com.au/podcast/melatonin-mechanisms-action-and-it%E2%80%99s-amazing-role-beyond-sleep-dr-adrian-lopresti-and-dr
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***DISCLAIMER: The information provided on fx Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***
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