COA in PROgress
How do we specify COA endpoints?
May 5, 2024
John Powers and Cheryl Coon discuss framing COA endpoints, emphasizing the importance of protocol clarity, treatment benefits, evidence, and patient-centric analysis. They also explore the complexities of specifying endpoints, the balance between specificity and broadness, and the innovative approach to developing outcome measures in clinical trials.
28:30
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Quick takeaways
- Specifying COA endpoints involves framing endpoints relevant to population, intervention, and timing for impact assessment.
- Endpoint selection in clinical trials requires reflecting treatment goals, disease progression, and aligning with regulatory frameworks.
Deep dives
Defining Endpoints and Outcome Measures in Clinical Trials
When considering clinical outcome assessments (COAs) in intervention development, the focus lies on specifying endpoints relevant to the population, intervention, context, and hypothesis. Endpoints encapsulate measures, including timing and estimated treatment effects, aiming to demonstrate the impact of interventions on patients' lives. Careful consideration of when and how to measure endpoints is vital, balancing the need for comprehensive data collection with participant burden.
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