Navigating the Complexity of Specifying Endpoints in Clinical Trials

The chapter explores the intricacies of specifying endpoints in clinical trials, emphasizing the balance between specificity and broadness, understanding patient perspectives, and making endpoints interpretable. It discusses the timing of assessments, variety of endpoints, and data collection frequency, highlighting the careful considerations required for effective endpoint specification. The conversation also touches on the relationship between different endpoints, the methods for specifying endpoints, and the challenges faced by sponsors in selecting the appropriate endpoint approach.