Demi Moore, renowned for her iconic roles in Hollywood, shares insights on the intense pressures middle-aged women face in the industry. She discusses her latest film, 'The Substance,' which tackles the dark side of aging and beauty standards. Moore opens up about navigating self-worth and loneliness amid these societal expectations. Critic John Powers adds a layer of intrigue discussing the South Park creators' renovation of Casa Bonita, revealing the emotional struggles tied to reviving cherished memories.

Evan Thomas, an author known for his deep dives into historical events, analyzes the crucial decisions that led to the atomic bombings during WWII. He discusses the moral dilemmas faced by U.S. leaders and the struggle of Japanese commanders in the face of defeat. Meanwhile, reviewer John Powers shares insights on 'The Instigators,' a new action comedy featuring Matt Damon and Casey Affleck, blending humor with heist chaos. Together, they navigate the complex legacy of war and entertainment.

John Powers and Cheryl Coon discuss framing COA endpoints, emphasizing the importance of protocol clarity, treatment benefits, evidence, and patient-centric analysis. They also explore the complexities of specifying endpoints, the balance between specificity and broadness, and the innovative approach to developing outcome measures in clinical trials.