The Optispan Podcast with Matt Kaeberlein

Debunking 10 Longevity Myths You Still Believe | 126

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Aug 28, 2025

Dive into the science behind longevity as myths are debunked! Discover why biological age isn't as straightforward as it seems, and learn about the limited role of supplements. Age isn't a barrier for improvement; your choices matter more than you think. Unpack the truths behind resveratrol and the surprising underfunding of aging research. Explore how genetics stack up against lifestyle choices when it comes to lifespan, and question the hype surrounding caloric restriction and new peptide therapies—it's time to rethink what you believe!

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INSIGHT

Biological Age Is An Estimate, Not A Measurement

We cannot directly measure biological age because we lack a full cellular and molecular definition of it.
Current tools estimate correlates (e.g., methylation) rather than true biological age and will only improve over time.

ADVICE

Choose Actionable Age Estimators

Use actionable estimators like blood-based mortality models and functional measures instead of epigenetic clocks.
Measure and fix drivers (e.g., A1c, hemoglobin) so you can change risk, and track VO2 max or grip strength.

ADVICE

Use Supplements Only When Measured

Treat supplements as situational tools you test for and correct, not core longevity pillars.
Take measurable supplements (vitamin D, omega-3, B vitamins, creatine) only when levels or needs justify them.

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Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements, this episode separates scientific fact from expensive fiction.0:00 - Intro: A New Series on Longevity Myths0:49 - Myth 1: Can You Actually "Measure" Biological Age?5:05 - Myth 2: Are Supplements a "Core" Longevity Strategy?6:29 - Myth 3 & 7: "I'm Too Old" & The Role of Your Genes8:16 - Myth 4 & 6: The FDA & The Truth About Research Funding10:49 - Myth 5: The Resveratrol Lie20:24 - Myth 8: The Caloric Restriction Misconception23:52 - Myth 9 & 10: The Reality of Rapamycin & PeptidesProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!