In this World Shared Practice Forum Podcast, Drs. Adrienne Randolph and Aaron Bodansky explore the groundbreaking research findings that uncover the pathophysiological mechanism behind multisystem inflammatory syndrome in children (MIS-C). These findings shed light on the characteristic immune response of patients who develop MIS-C, and provide insight into the development of post-infectious auto-immune disease phenotypes.
LEARNING OBJECTIVES
- Describe the pathophysiology of MIS-C, including the clinical features and molecular immune response
- Describe the immune dysregulation that results in MIS-C, including the role of autoantibodies and T-cell responses
- Identify the potential connections between SARS-CoV-2 infection and the development of autoimmune responses
- Recognize the implications of the study findings for other related conditions such as long COVID and sepsis
AUTHORS
Adrienne Randolph, MD, MSc
Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Professor of Anaesthesia and Pediatrics
Harvard Medical School
Aaron Bodansky, MD
Assistant Professor
Pediatric Critical Care
University of California, San Francisco School of Medicine
DATES
Initial publication: September 24, 2024.
ARTICLES REFERENCED
Bodansky A, Mettelman RC, Sabatino JJ Jr, et al. Molecular mimicry in multisystem inflammatory syndrome in children. Nature. 2024;632(8025):622-629. doi:10.1038/s41586-024-07722-4.
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CITATION
Randolph AG, Bodansky A, Burns JP. Unveiling MIS-C's Immune Response: Molecular Mimicry. 09/2024. OPENPediatrics. https://soundcloud.com/openpediatrics/unveiling-mis-cs-immune-response-molecular-mimicry-by-a-randolph-and-a-bodansky-openpediatrics
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