In this World Shared Practice Forum Podcast, Drs. Adrienne Randolph and Aaron Bodansky explore the groundbreaking research findings that uncover the pathophysiological mechanism behind multisystem inflammatory syndrome in children (MIS-C). These findings shed light on the characteristic immune response of patients who develop MIS-C, and provide insight into the development of post-infectious auto-immune disease phenotypes. LEARNING OBJECTIVES - Describe the pathophysiology of MIS-C, including the clinical features and molecular immune response - Describe the immune dysregulation that results in MIS-C, including the role of autoantibodies and T-cell responses - Identify the potential connections between SARS-CoV-2 infection and the development of autoimmune responses - Recognize the implications of the study findings for other related conditions such as long COVID and sepsis AUTHORS Adrienne Randolph, MD, MSc Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital Professor of Anaesthesia and Pediatrics Harvard Medical School Aaron Bodansky, MD Assistant Professor Pediatric Critical Care University of California, San Francisco School of Medicine DATES Initial publication: September 24, 2024. ARTICLES REFERENCED Bodansky A, Mettelman RC, Sabatino JJ Jr, et al. Molecular mimicry in multisystem inflammatory syndrome in children. Nature. 2024;632(8025):622-629. doi:10.1038/s41586-024-07722-4. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu CITATION Randolph AG, Bodansky A, Burns JP. Unveiling MIS-C's Immune Response: Molecular Mimicry. 09/2024. OPENPediatrics. https://soundcloud.com/openpediatrics/unveiling-mis-cs-immune-response-molecular-mimicry-by-a-randolph-and-a-bodansky-openpediatrics