The Curbsiders Internal Medicine Podcast

#357 Hotcakes: Ultra-short Antibiotics for Pneumonia, Acetazolamide for CHF, Psilocybin for AUD, and Asymptomatic Kidney Stone Removal

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Sep 28, 2022
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INSIGHT

Short Antibiotic Courses Need Context

  • Retrospective matching can't eliminate unmeasured differences that drive treatment decisions.
  • Propensity-matched shorter antibiotic courses looked safe only in patients likely not to have bacterial pneumonia.
ANECDOTE

Start Antibiotics 'Just In Case' Then Reassess

  • Paul described common hospital practice of 'start antibiotics just in case' and stopping once the diagnosis clarifies.
  • He illustrated this with patients who improve by day two and are often taken off antibiotics.
ADVICE

Stop Early Only With Clear Stability

  • Consider stopping antibiotics early only in patients who are clinically stable with high oxygen saturations.
  • Do not generalize ultra-short courses to all hospitalized pneumonia without clear evidence of bacterial infection.
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