Nutrition Facts with Dr. Greger More on NAD+ Boosting Supplements
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Oct 16, 2025 This discussion dives into the complex world of NAD+ and its boosting supplements. It highlights potential risks, including side effects related to metabolism and inflammation. The conversation also touches on the varying effects of NAD+ on cancer and the importance of lifestyle choices like exercise and diet in maintaining NAD+ levels. Mitochondrial health, dietary phytonutrients, and effective strategies to naturally increase NAD+ are examined. Overall, the episode encourages cautious consideration of supplements while emphasizing natural methods.
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Use Caution With NAD+ Supplements
- Avoid NAD+ boosters if you have cancer, active infections, or inflammatory autoimmune disease due to potential harm.
- Balance any possible anti-aging benefits against tumor-promoting or infection-exacerbating risks before using supplements.
No Proven Winner Among NAD Boosters
- There is no clear best NAD booster and human benefits remain unproven despite preclinical hype.
- Lack of patents limits funding for large, well-designed clinical trials on natural NAD precursors.
The Body Resists Blunt NAD Overload
- The body tightly regulates NAD and may suppress blunt precursor overload via feedback mechanisms like NAMPT suppression and methylation.
- Chronic supplementation might deplete methyl groups and could worsen NAD homeostasis when stopped.
