Neurology® Podcast
Bridging Therapy With Tenecteplase or Alteplase in Patients With Large Ischemic Core
Aug 8, 2024
Dr. Gaspard Gerschenfeld, a medical expert in thrombolytics, joins the conversation to discuss the implications of tenecteplase and alteplase in treating patients with large ischemic cores. He highlights a comparative study showing tenecteplase leads to better outcomes and lower mortality compared to alteplase at three months. The use of MRI versus CT scans in stroke assessment is also explored, emphasizing the importance of accurate imaging in urgent care. The dialogue stresses the need for further research to enhance stroke treatment efficacy.
12:20
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Quick takeaways
- Tenecteplase demonstrates superior functional outcomes and lower mortality in patients with large ischemic core strokes compared to alteplase.
- Both tenecteplase and alteplase exhibit similar safety profiles regarding hemorrhagic complications, supporting the choice of tenecteplase in practice.
Deep dives
Comparative Efficacy of Thrombolytics
The use of tenecteplase was shown to result in better functional outcomes and lower mortality rates for patients with large ischemic core strokes compared to alteplase. In a study involving two registries, tenecteplase demonstrated a significant advantage in the three-month assessment of patient recovery. This finding emphasizes the potential benefits of tenecteplase, particularly for severe stroke cases undergoing bridging therapy before thrombectomy. Such outcomes highlight the importance of considering thrombolytic agents carefully in clinical practice.
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