Dr. Justin Abbatemarco talks with Dr. Josep Dalmau about the evolution of Neurology: Neuroimmunology & Neuroinflammation over the past decade, and how it has emerged as a leading journal in clinical and translational neuroimmunology. Read the related article in Neurology: Neuroimmunology & Neuroinflammation. Disclosures can be found at Neurology.org.

Dr. Adam Rodman, a physician at Beth Israel Deaconess Medical Center and expert in large language models, discusses the revolutionary impact of AI on clinical reasoning. They explore the O1 model's superior diagnostic performance compared to previous iterations like GPT-4. The conversation delves into how enhanced machine reasoning abilities could transform neurology and reduce human error. Rodman emphasizes the importance of physicians in shaping technology policy to ensure responsible integration of these tools into patient care while maintaining the human touch in medicine.

Dr. Derek Stitt talks with Dr. Miranda M. Wan about improving training and public awareness to optimize palliative care for patients with neurologic conditions. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.

Dr. Adrian Budhram, a neurologist known for his expertise in autoimmune encephalitis, discusses the complexities of cerebrospinal fluid (CSF) analysis after traumatic lumbar punctures. He highlights the challenges neurologists face with red and white blood cell contamination and the research gaps in correction factors for accurate diagnoses. Patient anxiety during these procedures also becomes a focal point, emphasizing the importance of effective doctor-patient communication. Ultimately, the conversation stresses the significance of clinical judgment in interpreting CSF results.

Dr. Simon Ducharme, a senior author from McGill University, dives into intriguing findings on sleep dysfunction related to genetic frontotemporal dementia (FTD). He discusses the impact of MAPT gene mutations on sleep patterns and emphasizes the role of genetic testing for early diagnosis. Ducharme highlights the association between hypothalamic structural changes and sleep issues, along with the need for effective treatment strategies. He also explores the significance of managing sleep disorders in improving care for FTD patients.

In this talk, Nicolás Lundahl Ciano-Petersen, a researcher with expertise in paraneoplastic neurological syndromes, shares fascinating insights on the rare connection between these syndromes and Merkel cell carcinoma. He discusses the intriguing clinical profiles of patients, including symptoms like Lambert-Eaton myasthenic syndrome. Lundahl also highlights the potential for spontaneous tumor regression and emphasizes the need for multidisciplinary approaches in diagnosis and treatment, given the complexities surrounding these disorders.

Dr. Tesha Monteith talks with Dr. Ashish D. Patel about headache referrals and the implementation of a design thinking approach to improve access to headache care. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.  

Dr. Andy Southerland talks with Dr. Scott Friedenberg about the challenges faced by neurologists in balancing financial productivity with optimal patient care Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.

Ring in the new year with the January 2025 replay of previously released episodes discussing the rise of science sleuths. In this three-part series Dr. Stacey Clardy talks with Dr. Elisabeth Bik and Dr. Matthew Schrag about critical issues surrounding research integrity and misconduct. Podcast Links: The Rise of the Science Sleuths - Part 1 The Rise of the Science Sleuths - Part 2 The Rise of the Science Sleuths - Part 3  Article Link: The Rise of the Science Sleuths  Disclosures can be found at Neurology.org.

Dr. Brian Edlow, a neurocritical care expert at Massachusetts General Hospital, and Dr. Yelena Bodine, an assistant professor at Vanderbilt University, dive into cognitive motor dissociation (CMD) within neurocritical care. They discuss how some patients presumed to be in a coma may actually process thoughts with advanced imaging techniques like fMRI and EEG. The guests address ethical challenges in using these technologies and advocate for improved access for underserved populations, emphasizing the need for 'prognostic humility' in patient assessments.