Quick takeaways

• Clozapine can cause severe constipation due to its anticholinergic effects, and managing constipation effectively is crucial to prevent serious medical complications.

• To manage constipation caused by clozapine, it is important to gradually discontinue other systemically-acting anticholinergic medications, taper off non-psychiatric anticholinergic medications, temporarily stop supplemental iron, encourage reporting lack of bowel movement, maintain fluid intake and exercise regularly, and consider appropriate laxatives if needed.

Deep dives