Psychopharmacology expert, Jonathan Meyer, M.D., talks about the severe side effect of clozapine: constipation. He discusses the cause of constipation due to the drug's strong anticholinergic effects and effective management strategies such as using laxatives and tapering certain medications. The podcast also highlights the importance of managing treatment-resistant illness and provides insights on secretagogues for constipation in clozapine users.

Dr. Jonathan M. Meyer, a Voluntary Clinical Professor at UC San Diego and psychopharmacology expert, discusses the evolution of muscarinic-targeting treatments for schizophrenia. He highlights the historical shifts from dopamine-centric therapies to the promising role of muscarinic receptors. Key topics include the challenges and innovations in cognitive impairment management, new drugs like xanomeline-trospium, and the impact of neurotransmitter interactions. Meyer emphasizes tailored treatment approaches and the importance of individualized dosing strategies for enhancing patient outcomes.