Zonulin: what nutrients to look at if it's high? | Masterjohn Q&A Files #224
Jun 30, 2021
09:20
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question_answer ANECDOTE
Listener Reports Very High Zonulin Reading
A listener's wife had a zonulin reading around 360 on a Vibrant/Genova stool panel and it flagged as very high.
They were puzzled because other tests for SIBO and methane were negative despite inflammatory gut symptoms.
insights INSIGHT
Zonulin Indicates Gut Permeability
Zonulin is interpreted as a marker of intestinal permeability and can reflect gut inflammation or barrier dysfunction.
Chris Masterjohn links biochemical drivers like arachidonic acid and prostaglandin E2 to gut immune tolerance and junction integrity.
volunteer_activism ADVICE
Check Arachidonic Acid And EPA Balance
Check arachidonic acid levels on an omega panel because gut-associated lymphoid tissue uses arachidonic acid to form prostaglandin E2 and support tolerance.
Also compare EPA to arachidonic acid position in the range because high EPA can inhibit conversion to prostaglandin E2 and affect tolerance.
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Plenty more at https://chrismasterjohnphd.com/support! Question: Zonulin: what nutrients to look at if it's high? I think of that from my perspective, which is much more focused on nutrients and biochemistry, I'm thinking especially if you have the ION panel, which kind of takes apart my end of the spectrum, actually I would look at arachidonic acid levels because arachidonic acid in the gut is associated with lymphoid tissue, is metabolized to prostaglandin E2, which promotes immune tolerance.
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.
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