Understanding the complex nature of NAD and its precursors

NAD is an essential molecule for cellular life and plays a crucial role in energy production, immune cell signaling, and DNA repair. However, as we age or experience certain health conditions, the levels of NAD can become depleted due to the upregulation of certain enzymes like CD38 and NNMT. This depletion is particularly problematic in senescent cells, cancer cells, and inflammatory cells. While NAD precursors like NMN and NR are often promoted as a way to boost NAD levels, it's important to consider the balance and timing of supplementation. Taking high doses of NAD precursors continuously can lead to further depletion due to the increased activity of the enzymes. It's recommended to periodically supplement with lower doses of NAD precursors, while also using CD38 blockers like Apigenin or Quercetin. Additionally, the upcoming supplement 1MNA shows promise in selectively feeding excess NAD into more beneficial pathways. It is crucial to remember that there is still much we don't know about the optimal dosing and timing of NAD-related supplementation, highlighting the need for cautious and informed decision-making.