How to Naturally Boost GLP-1, Reduce Cravings, & Lose Weight Faster - With Dr. Karan Rajan

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Nov 3, 2025

Dr. Karan Rajan, a physician and founder of Loam Science, dives into the fascinating world of gut health and satiety hormones. He reveals how certain foods, like fiber and healthy fats, can naturally boost GLP-1 levels to improve weight loss. Dr. Rajan explores the gut-brain connection and the role of sensory experiences in digestion. Discover the benefits of mindful eating, the importance of dietary diversity for microbiome health, and how cooking methods can mitigate anti-nutrients in beans.

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INSIGHT

Fiber Plus Protein Boosts Satiety Hormones

Soluble fermentable fibers and high-protein foods together stimulate GLP-1 and PYY, improving satiety naturally.
Foods that reach the colon and are fermented by microbes prolong GLP-1 elevation and reduce hunger.

ADVICE

Use Fats And Polyphenols To Increase Fullness

Include healthy fats to stimulate CCK and slow gastric emptying for greater fullness.
Eat darkly colored polyphenol-rich foods like berries or coffee to upregulate GLP-1 gene expression.

ADVICE

Add Spice To Reduce Appetite

Add spice (capsaicin) to meals to activate TRPV1 receptors and mimic heat, which can reduce subsequent food intake.
Try hot sauces or chili on fruit for enhanced satiety from flavor contrast.

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In the age of GLP-1 medications, there’s a lot of talk about what causes satiety. Because GLP-1 agonists aid in weight loss by mimicking your body’s natural hormones, there are certain lifestyle factors that can naturally activate the stimulation of GLP-1 in your body. Today, you’re going to learn about the science of satiety hormones and the truth about the gut-brain connection.

On this episode of The Model Health Show, our guest is world renowned surgeon and educator, Dr. Karan Rajan. You’re going to learn about the important connection between the gut and the brain, the science of GLP-1 receptors, and specific foods you can eat to improve your health.

Dr. Karan Rajan has a wealth of knowledge in the realm of gut health, and he has an interesting and entertaining way of explaining things that I know you’re going to love. Click play to learn more about satiety, gut health, and how to eat for better health. Enjoy!

In this episode you’ll discover:

How food can stimulate satiety hormones. (5:33)
The two food groups you should eat to improve satiety. (6:43)
Why eating healthy fats is critical for increased satiety levels. (10:35)
The importance of flavonoids and polyphenols. (10:54)
How environmental exposures impact immune health. (19:33)
Why perception plays a role in taste. (23:13)
The connection between overeating and eating too quickly. (31:45)
What to consider about the anti-nutrients in plant foods. (32:58)
Which system develops first in the human body. (34:45)
The bidirectional connection between the brain and the gut. (35:56)
Which foods to eat for better gut health. (45:47)
How to add more fermented foods into your diet. (47:37)
The role hydration plays in gut health. (55:51)

Items mentioned in this episode include:

Paleovalley.com/model - Use code MODEL for 15% off!
Piquelife.com/model - Get exclusive savings on bundles & subscriptions!
This Book May Save Your Life by Dr. Karan Rajan - Get your copy today!
LoamScience.com - Learn more about helping your microbiome thrive!
Connect with Dr. Karan Rajan Website / Podcast / Instagram / TikTok / YouTube

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This episode of The Model Health Show is brought to you by Paleovalley, & Pique.

Use my code MODEL at Paleovalley.com/model to save 15% sitewide on nutrient dense snacks, superfood supplements, and more.

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