The Peter Attia Drive Qualy #19 - A unifying theory of aging
Sep 5, 2019
David Sinclair, Ph.D., a leading expert on aging and epigenetics, dives deep into the science of slowing aging. He introduces a captivating unifying theory of aging that contrasts stable genomic data with the fragile nature of epigenetics. The conversation highlights groundbreaking research in longevity and the significant role of sirtuins in DNA repair. Sinclair shares insights on how aging affects cellular identity and discusses innovative approaches that could eventually redefine our understanding of aging.
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Unifying Theory of Aging
- Aging is driven by a breakdown in how genes are expressed, not gene damage.
- This breakdown is like a scratched CD; the information is there, but it's misread.
Digital vs. Analog Aging
- The genome is digital and robust like a CD, while gene expression is analog and degrades over time like a record.
- This degradation causes cells to lose their identity and function, contributing to aging.
Waddington's Landscape Analogy
- Waddington's Landscape visualizes cell identity as marbles settling into valleys.
- Aging disrupts this, causing marbles to jump valleys and cells to lose identity.