The Genius Life 539: The One Gut Mistake Fueling Inflammation and Wrecking Your Digestion | Will Bulsiewicz, MD
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Jan 5, 2026 
Dr. Will Bulsiewicz, known as 'Dr. Will,' is a gastroenterologist and gut-health expert, author of 'Plant Powered Plus.' In this conversation, he delves into chronic inflammation's roots in gut health, linking it to over 130 health conditions. Dr. Will explains why the modern diet and lifestyle undermine gut integrity and emphasizes fiber's vital role in promoting longevity. He also reveals practical steps for gut healing, highlights the perils of ultra-processed foods, and even shares insights on proper pooping positions for better digestion.
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Inflammation: Helpful Until It’s Chronic
- Inflammation is a protective immune response that becomes harmful when it becomes chronic and low-grade.
- Chronic low-grade inflammation damages organs and contributes to fatigue, brain fog, joint pain, and metabolic disease.
Gut Is The Immune System’s Home
- The gut houses about 70% of immune cells and acts as a three-layer defense: microbes, gut barrier, then immune system.
- If microbes weaken and the gut barrier breaks, intestinal permeability triggers chronic inflammation.
Gut Healing Is Rapidly Regenerative
- Many modern diseases link back to gut dysbiosis, intestinal permeability, and inflammation across organs.
- Healing the gut microbiome can rapidly repair the gut barrier because the intestinal lining renews every 3–5 days.
