

23 - The truth about GLP-1s, weight loss and nutrition with Dr Jack Mosley
Sep 2, 2025
In this discussion, Dr Jack Mosley, a GP registrar and the son of renowned health writer Dr Michael Mosley, sheds light on GLP-1 medications like Ozempic and Wegovy. He explains their effectiveness, risks, and how they fit into the broader landscape of weight management. The conversation emphasizes the need for a holistic approach to health, combining medication with lifestyle changes. Jack also reflects on his father's legacy and the future of medicine, making for a thoughtful and engaging exploration of contemporary health challenges.
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Environment Drives Overeating
- We live in a toxic food environment where processed foods are engineered to overwhelm satiety and drive addictive eating.
- This environment plus stress and long shifts in healthcare makes weight gain very easy and hard to reverse.
Personal Weight Changes Shared
- Michael Mosley reversed his type 2 diabetes by losing around 10 kg and reducing liver and visceral fat.
- Jack Mosley also gained 15 kg as a junior doctor and later lost it with small sustainable changes.
Visceral Fat Is The Dangerous Type
- Visceral fat is metabolically active and raises risk for diabetes and cardiovascular disease.
- Subcutaneous fat is less harmful, so body composition matters more than appearance alone.