The Energy Blueprint Podcast Alzheimer's Is Optional | Preventing And Reversing Cognitive Decline with Dale Bredesen, MD
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Nov 1, 2025 
Dr. Dale Bredesen, expert in preventing and reversing cognitive decline, discusses root causes of cognitive decline, downsizing network, link between cognitive demands and Alzheimer's, relationship between fruit consumption and cognitive decline, role of ketosis in a ketogenic diet, relationship between vascular issues and dementia, and efficacy of drug treatments for Alzheimer's.
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From Molecules To Lifestyle Shift
- Dale Bredesen recounts initially aiming to find a single protein fold and a drug to fix Alzheimer's.
- His wife's integrative perspective led him to recognize lifestyle and energetics as central drivers of brain health.
Alzheimer's As Network Insufficiency
- Alzheimer's is best seen as a network insufficiency driven by energetics and inflammation.
- When supply chronically fails demand, the brain downsizes synapses and circuits.
Cognitive Demand Shapes Brain Health
- 'Use it or lose it' explains part of cognitive decline: reduced cognitive demand downregulates repair and growth.
- However, disuse alone doesn't explain all cases; pathogens and inflammation also drive decline.