HDL Cholesterol with Dr. Mark Houston: Rational Wellness Podcast 203
Apr 21, 2021
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Dr. Mark Houston discusses the complexity of HDL cholesterol, its implications for heart disease prevention, and the limitations of drugs developed to raise HDL. The podcast also covers the detection of soft plaques in arteries and alternative methods for accurate detection. Furthermore, it explores the positive functions of HDL cholesterol, challenges in delivering substances into the bloodstream and cells, and the use of coke uten and supplements for improving cardiac health. The benefits of intermittent fasting, exercise, and niacin supplementation on cardiovascular health are also discussed.
HDL functionality is crucial for protection against heart disease, and nutraceuticals and lifestyle interventions can improve it.
Reverse cholesterol transport (RCT) plays a crucial role in preventing atherosclerosis and improving cardiovascular health, and measuring HDL functionality can provide valuable insights into an individual's risk for heart disease.
Deep dives
The Importance of HDL Cholesterol in Preventing Cardiovascular Disease
HDL cholesterol, commonly known as the 'good cholesterol,' plays a significant role in preventing and reversing cardiovascular disease. Unlike the focus on LDL cholesterol, which is considered the 'bad cholesterol,' HDL cholesterol has been found to have multiple benefits. The functionality of HDL is crucial, as simply having high levels of HDL does not guarantee protection against heart disease. Drugs developed to raise HDL levels have not been successful in reducing heart attacks or death. Tests to measure HDL functionality exist and can provide a more accurate assessment of an individual's risk for coronary heart disease. Improving HDL functionality can be achieved through nutraceuticals and lifestyle interventions, such as a low-carbohydrate diet, exercise, and fasting.
Reverse Cholesterol Transport and its Role in Heart Health
Reverse cholesterol transport (RCT) is a primary function of HDL cholesterol. HDL particles attach to cell walls, pick up LDL cholesterol, and carry it to the liver for excretion. Effective RCT plays a crucial role in preventing atherosclerosis and improving cardiovascular health. Dysfunctional HDL, on the other hand, leads to LDL accumulation in the cells and the progression of atherosclerosis. HDL also plays a role in reducing plaque stability, preventing plaque rupture, and reducing the risk of acute myocardial infarction. Laboratory tests can measure HDL functionality and provide valuable insights into an individual's risk for heart disease.
Measuring HDL Functionality and Addressing Dysfunction
Measuring HDL functionality is crucial in accurately assessing an individual's risk of cardiovascular disease. Tests that determine HDL particle number and HDL functionality provide a more comprehensive understanding of HDL's protective effects. While traditional measures like total HDL levels and particle size were once considered indicative of good heart health, they have proven to be inadequate predictors of actual risk. Drugs developed to raise HDL levels have mostly been unsuccessful due to their inability to improve HDL functionality. However, specific nutraceutical compounds, like cardiolux, have shown promise in improving HDL functionality, particle number, and size.
Diet, Lifestyle, and Supplement Strategies for Improving HDL Functionality
Adopting a low-refined carbohydrate diet with an emphasis on vegetables and high-quality proteins can help improve HDL functionality. Incorporating specific supplements, such as niacin, pomegranate, curcumin, and quercetin, has been shown to enhance HDL function, reduce oxidative stress, inflammation, and immune dysfunction. Additionally, exercise, including aerobic and resistance training, has been found to positively impact HDL parameters and overall cardiovascular health. A comprehensive approach that combines these strategies and personalized interventions can help optimize HDL functionality and reduce the risk of heart disease.