Sigma Nutrition Radio #577: Ultra-processed vs. Minimally Processed Diets: UPDATE Trial – Samuel Dicken, PhD
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Sep 16, 2025 Dr. Samuel Dicken, a Research Fellow at UCL and lead author of the UPDATE trial, dives into fascinating insights from his groundbreaking research on ultra-processed versus minimally processed diets. He discusses how these diets affect cravings and appetite regulation, challenging the notion of what constitutes a healthy eating pattern. With potential policy implications addressed, Dr. Dicken emphasizes the urgent need for systemic changes to improve food accessibility, particularly for disadvantaged communities. Tune in for a thought-provoking exploration of our dietary choices!
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Research Path Triggered By Kevin Hall Trial
- Samuel Dicken transitioned from clinical science in the NHS to researching ultraprocessed food after Kevin Hall's 2019 trial influenced him.
- That trial's inpatient findings motivated him to study whether processing matters beyond nutrient profiles.
Processing Vs Dietary Guidance
- The UPDATE trial tested ultra-processed vs minimally processed diets both aligned to UK Eat Well guidance to see if processing adds risk beyond nutrients.
- This isolates whether NOVA provides extra, policy-relevant information beyond existing dietary guidance.
Design Trials To Be Realistic And Controlled
- Use a randomized crossover design so participants act as their own controls to minimise confounding in diet trials.
- Provide meals and keep instructions neutral to reduce behavioural biases and improve generalisability.