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The Journal.
Trillion Dollar Shot, Episode 1: Birth of a Blockbuster
May 13, 2024
Explore the journey of Lotte Bjerre Knudsen, whose innovative work on GLP-1 transformed diabetes treatment into a blockbuster weight loss solution. Delve into the emotional complexities of using weight loss medications, revealing personal stories and societal impacts. Discover the rivalry among pharmaceutical giants aiming for the trillion-dollar mark and the ethical concerns surrounding drug accessibility and affordability. Uncover how a diabetes drug became a celebrity-endorsed phenomenon and the psychological struggles faced by those without it.
41:21
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Quick takeaways
- GLP-1 drugs like Ozempic were developed for diabetes but transitioned to obesity treatment, showcasing significant weight loss effects.
- The success of GLP-1 drugs has led to a booming market with societal impacts, but ethical concerns arise over high costs and off-label prescriptions for weight loss.
Deep dives
The Development of GLP-1 Drugs for Diabetes Treatment
The podcast delves into the story of how GLP-1 drugs, like Ozempic, were developed to treat diabetes. It follows the journey of the scientist Lauda Bier-Konutsen at Novo Nordisk in the 1990s as she worked on creating a compound mimicking the GLP-1 hormone. Despite setbacks, including tumorigenesis concerns in animal studies, the team eventually succeeded with a long-acting GLP-1 compound, leading to the approval of Liraglutide in 2010.
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