The Proof with Simon Hill

Why we age and how to slow it | Venki Ramakrishnan

Oct 7, 2024

Venki Ramakrishnan, a Nobel Prize-winning structural biologist, dives into the fascinating science of aging. He explores why and how we age, highlighting the pivotal role of ribosomes in protein synthesis. Ramakrishnan addresses misleading anti-aging claims, the complex interplay of genetics, and the true meaning of 'biological age.' Listeners gain insights into practical strategies for slowing aging, the effects of lifestyle choices on longevity, and the promise of regenerative medicine. His engaging discussion challenges perceptions of aging and encourages a scientific approach to longevity.

01:50:31

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Venki Ramakrishnan

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Quick takeaways

Ribosomes are crucial in protein synthesis, and their dysfunction can accelerate aging, highlighting the need for proper ribosomal function to promote longevity.

The growing field of longevity science requires critical evaluation of anti-aging claims due to its blend of valid research and commercial interests that may lack scientific backing.

Lifestyle choices such as exercise, nutrition, and sleep play a significant role in cellular repair and overall healthspan, positively impacting the aging process.

Deep dives

The Intersection of Ribosomes and Aging

Ribosomes play a crucial role in protein synthesis, which is fundamental to the biological processes that underlie aging. The speaker explains that when ribosome function is impaired, it can lead to accelerated aging due to incorrect protein synthesis and degradation. This connection between ribosomes and aging highlights the importance of maintaining their proper function to slow down the aging process. The research on this relationship suggests that understanding ribosomes could provide insights into potential interventions for age-related decline.

Reprogramming Cells: A New Life Potential

01:30

Balance Between Risks and Benefits in Genetic Traits

01:18

Caloric Restriction: Weighing Benefits Against Drawbacks

01:08

Evolution Sets Lifespan Limits

01:05

Intro

2min

Ribosomes, Research, and the Reality of Aging

21min

Exploring Human Lifespan and Aging

7min

The Paradox of Aging and Regeneration

8min

Measuring Aging: Markers and Interventions

5min

Aging and Antagonistic Pleiotropy

20min

Unraveling Aging: Hallmarks and Protein Synthesis

8min

Calorie Restriction: Promise and Perils

6min

Understanding DNA Damage and Repair

11min

10.

Aging, Health, and Longevity: A Complex Exploration

16min

Episode #334. Can we turn back the clock on our biology? Join me as I sit down with Nobel Prize-winning structural biologist Dr Venki Ramakrishnan to discuss why we age, how we age, and the scientific advancements helping us live longer and healthier lives.

In this episode, you'll learn about the core reasons behind aging, the role of ribosomes and DNA damage in this process, and the science behind popular longevity interventions. Dr Ramakrishnan shares his insights on misleading anti-aging claims, how much control we truly have over aging, and the truth about "biological age". We also explore practical ways to slow down aging and extend our healthspan.

Specifically, we discuss:

Introduction to Aging and Longevity Science (00:00)
Ribosomes and Their Role in Longevity Research (00:57)
Controversies in Anti-Aging Research (05:09)
Understanding the Biology of Aging (11:25)
Genetics and Evolution: How They Shape Human Lifespan (22:10)
Youthful Cells: The Future of Longevity Studies (29:38)
Biological Interventions in Aging: Potential and Risks (46:09)
Ancestral Living and Traditional Medicine for Longevity (52:09)
Cellular Aging Mechanisms: A Deeper Look (56:51)
Protein Synthesis and Its Impact on Aging Processes (01:04:19)
DNA Damage and Repair: Implications for Aging (01:16:53)
Lifestyle Choices That Influence Aging and Lifespan (01:24:03)
Philosophical Perspectives on Extended Human Longevity (01:32:53)
Concluding Thoughts on Aging and Longevity Research (01:43:21)

Learn more about Dr Venki Ramakrishnan here, and be sure to check out his books Gene Machine and Why We Die.

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Simon Hill, MSc, BSc (Hons)

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