20min chapter

The Proof with Simon Hill cover image

Why we age and how to slow it | Venki Ramakrishnan

The Proof with Simon Hill

CHAPTER

Aging and Antagonistic Pleiotropy

This chapter examines the dual role of genetics in aging, focusing on antagonistic pleiotropy where early-life beneficial genes can lead to negative outcomes in later life. It discusses the mechanisms of telomere shortening, cellular senescence, and the implications for cancer and inflammation, all while considering the complexity of interventions aimed at extending lifespan. The conversation also questions the validity of ancestral living practices and emphasizes the importance of scientific validation in understanding aging and longevity.

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