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In this podcast episode, chemist, journalist, and celebrity documentarian Hamilton Morris explores the significance of personal experiences in comprehending the effects of drugs. He emphasizes the limitations of reductionist neuroscientific frameworks and highlights the value of direct experience as a powerful tool for analyzing psychoactive substances. Morris shares insights from his research and documentary series, illustrating the importance of individual perspectives in understanding the complexities of psychedelic substances. He also delves into the history and archaeology of drug use, including the intriguing evidence of ancient bufotenin-containing seeds and their role in prehistoric rituals. Through thought-provoking discussions, Morris challenges conventional narratives and encourages a more nuanced exploration of psychedelic substances.