Huberman Lab Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
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Oct 30, 2025 
Dr. David Sinclair, a Harvard genetics professor and longevity researcher, explores the biology of aging and interventions to slow it down. He argues that aging should be treated as a disease and introduces concepts like the epigenome as the key to understanding aging. Sinclair shares practical tips on fasting and exercise to activate longevity pathways. He discusses how dietary choices influence biological age and even touches on the potential for rejuvenating fertility through NMN. Tune in for insights that could change your perspective on aging!
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Reframe Aging As The Root Disease
- Aging should be considered a disease because it is deterioration that causes most major diseases like heart disease and Alzheimer's.
- Slowing or reversing aging could prevent those diseases rather than treating them after they appear.
Epigenome Controls Most Longevity
- The epigenome—marks that control which genes are on or off—drives about 80% of future health and longevity.
- Aging equals loss of information in the epigenome, causing cells to lose identity and function.
Scratched Epigenome Causes Cellular Misidentity
- ‘‘Scratches’’ on the epigenome (like methylation changes) cause genes to be mis-expressed in wrong cells or times.
- This loss of gene-control leads cells to forget their roles and produces age-related dysfunction.