36. Jalal Khan: Circadian Biology, Mitochondria, POMC and Why You Need Sunlight for Optimal Health
Sep 3, 2023
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Dr. Jalal Khan, quantum health clinician and practicing dentist, discusses circadian biology, mitochondrial dysfunction, and the role of POMC and melanin in optimal health. Topics include the centrality of circadian biology, the effect of unseasonal eating on mitochondria, the reduction of deuterium with animal-based diets, the role of UV light for our biology, and the incredible functions of melanin in biology.
Circadian biology is central to health and should be corrected for optimal well-being.
Food carries information based on light environment and maintaining alignment with seasons and locality optimizes mitochondrial function.
Understanding POMC and its response to light is crucial for optimizing health and longevity as it coordinates various bodily processes.
Deep dives
The Concept of Quantum Health and Circadian Biology
Quantum health is a model of healthcare that recognizes the energetic nature of our bodies and the role of light in influencing our health. It emphasizes that our bodies operate on scales of energy and information flow, and understanding this can change the way we approach healing. Circadian biology, which is closely tied to quantum health, explores how light regulates the various cycles and pathways within our body. The importance of correcting circadian rhythms is highlighted as the foundation for any health or healing journey.
Food as an Electromagnetic Barcode and the Importance of Eating Seasonally and Locally
Food is not just a source of energy and nutrients, but it also carries information based on the light environment in which it was grown. This is referred to as the electromagnetic barcode of food. The frequencies of light that are absorbed by plants during photosynthesis are stored in the food as energy and information. Eating seasonally and locally aligns our diet with the light environment we live in, optimizing the harmony between food and our mitochondrial function. Deviating from this natural alignment can result in mitochondrial dysfunction, energy breakdown, and adverse health outcomes.
The Significance of POMC in Coordinating Metabolism and Circadian Rhythms
POMC (protomelanocortin) is a polypeptide hormone that plays a central role in coordinating various bodily processes, including metabolism and the regulation of circadian rhythms. Expressed in key areas like the eyes, skin, gut, and the hypothalamus, POMC acts as a master coordinator. Leptin, a hormone that carries information about energy levels in the body, interacts with POMC through leptin receptors, influencing the cleavage of POMC into different proteins like alpha MSH. These proteins then impact processes like melanin production and appetite control. Understanding POMC and its role in response to light, both from the environment and internal sources, is crucial for optimizing health and longevity.
The Role of Mitochondria in Disease
The podcast episode discusses how mitochondrial dysfunction can lead to disease. It explains that for many people, diseases are not caused by a single gene mutation, but rather a cumulative degradation in the mitochondria's ability to produce energy. The episode emphasizes that mitochondria are not just energy producers, but also act as environmental sensors. It highlights that the proteins involved in the electron transport chain of mitochondria are sensitive to different frequencies of light, such as UV light and red light. It further explores how exposure to UV light can slow down the electron transport chain, making the body more thermodynamically efficient.
The Importance of Melanin and UV Light
The episode delves into the significance of melanin and UV light in human biology. It explains that melanin, found in skin, hair, and other tissues, can absorb all visible light and even non-visible light, such as UV and infrared light. Melanin plays a crucial role in detoxifying heavy metals and clearing reactive oxygen and nitrogen species. It also discusses the hormone melatonin, which is produced in the pineal gland and mitochondria and helps regulate sleep and repair processes. The episode challenges the notion that UV light should be avoided due to melanoma risk and emphasizes the importance of sensible sun exposure and optimal melanin levels for overall health.
Dr Jalal Khan is one of Australia’s leading quantum health clinicians as well as a practicing dentist. In this fascinating conversation we cover Jalal’s thoughts on the centrality of circadian biology to health, why diet-only health paradigms lack the complete picture, role of mitochondrial dysfunction and disease, pro-opiomelanocortin (POMC), melanin and much more.
TIMESTAMPS 00:01:39 What is Quantum health & circadian biology?
00:07:07 How is food just a form of light? The effect of unseasonal eating on your mitochondria
00:14:00 Why carnivore and animal based diets work: reducing deuterium
00:15:45 Dr Max: Contribution of fruit to metabolic syndrome is dependent on latitude and circadian regulation
00:21:10 Invitation for practitioners to consider the context of their patients when reversing disease
00:23:35 What is deuterium?
00:29:40 Understanding mitochondrial heteroplasmy and mitochondrial dysfunction
00:35:30 Mitochondria as environmental light sensors, the need for UV light for our biology
00:45:30 The essential role of melatonin
00:49:00 Pro-opiomelanocortin (POMC) is the master regulator of energy metabolism
00:57:40 Dr Max: theme park ticket analogy of POMC and its evolutionary history
01:04:20 Melanin allows us to harvest energy from UV light
01:08:00 The incredible functions of melanin in biology
01:16:45 Reflections on the recent REGNERATE health summit, preview of upcoming Quantum Health Summit