Benefits of Glycine for Longevity

Glycine has been shown to extend lifespan in worms, mice, and rats. It improves health and age-related diseases in mammalian models. Glycine induces autophagy and mimics methionine restriction, two mechanisms linked to longevity. Methionine restriction has been found to extend the lifespan in rodents. Glycine mimics the effects of methionine restriction without the need to restrict methionine in the diet. The ratio between methionine and glycine is crucial, and glycine buffers against methionine toxicity.