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High Performance Health

Spermidine: The Anti-Aging Molecule Every Perimenopausal Woman Should Know About | Leslie Kenny

Mar 30, 2025
Leslie Kenny, a Harvard-educated CEO and expert in longevity, shares her inspiring story of reversing her biological age to 21. She emphasizes the importance of diet, sleep, and social connections for health optimization. The power of spermidine, found in plant-based foods, is discussed as a vital contributor to autophagy, immune health, and even hair pigmentation. Leslie highlights the unique microbiome's impact on nutrition and advises on identifying dietary 'kryptonite' to enhance wellness, particularly for women in perimenopause.
01:03:48

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Quick takeaways

  • Adopting a multifactorial approach that includes diet, movement, sleep, and social connection is essential for optimal health and longevity.
  • Prioritizing quality sleep is crucial as it significantly impacts cognitive health, particularly in reducing risks of conditions like Alzheimer's.

Deep dives

The Role of Spermidine in Cellular Renewal

Spermidine is a powerful molecule that supports autophagy, the process through which cells recycle and renew themselves. It acts like a 'trash bag' for cells, clearing out waste and dysfunctional components, including mitochondria and viruses. This capability positions spermidine as a crucial factor in combating aging, as it targets nine out of twelve recognized hallmarks of aging. Its potential benefits extend to immune health and overall cellular function, making it an important dietary component for longevity and wellness.

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