What You Need to Know About Estrogen and Serotonin - Discussion Between Georgi Dinkov & Dr. Mercola
Oct 22, 2023
auto_awesome
Dr. Mercola and Georgi Dinkov discuss the downsides of estrogen and debunk the myth of serotonin as the happy hormone. They explore the effects of estrogen in weight gain, breast cancer, and hormone replacement therapy. The podcast also delves into the relationship between estrogen, EMF, and the electron transport chain, the use of RE486 and DHT in cancer treatment, the effects of progesterone on the body, and the connection between serotonin and GABA. They also discuss the effectiveness of GABA, theanine, and magnesium supplements for anxiety and sleep, utilizing fat as fuel for endurance athletes, the role of nitric oxide, and the significance of subscribing to a health blog.
Estrogen replacement therapy comes with numerous risks, including heart attacks, strokes, Alzheimer's disease, Parkinson's disease, and various cancers.
Progesterone and pregnenolone play important roles in hormone modulation and have calming effects when taken with long-chain fatty acids.
Serotonin is linked to depression, insomnia, and gut disorders, and treating these issues with GABA can be safer and more effective than conventional medications.
Maintaining balanced hormone levels is crucial for overall health, and progesterone and pregnenolone offer promising alternatives for hormone balance and modulation without the potential risks associated with conventional treatments.
Deep dives
Progesterone and Estrogen: The Controversy and Risks
Contrary to popular belief, estrogen is not as beneficial as it is often portrayed. The Women's Health Initiative study revealed that estrogen replacement therapy increased the risks of heart attacks, strokes, Alzheimer's disease, Parkinson's disease, and various cancers. Estrogen has been identified as a known human carcinogen by the National Institutes of Health. Estrogen is also involved in the development of estrogen receptor positive breast cancer. Furthermore, the decline of pro-differentiation factors, such as progesterone and androgens, with age can contribute to the negative effects of estrogen. It is important to consider the potential risks of estrogen therapy and to focus on maintaining balanced hormones.
The Role of Progesterone and Pregnenolone
Progesterone and pregnenolone play significant roles in hormone modulation. Progesterone is a powerful sedative and cortisol blocker. It can help with conditions like obesity by restoring metabolic dysfunction. Pregnenolone acts as a precursor for various steroids and can balance hormone levels. Both progesterone and pregnenolone have calming and relaxing effects. To maximize their effectiveness, oral administration with long-chain fatty acids, like butter or cacao butter, is recommended. Dosages vary based on individual needs with physiological doses ranging from 10-30 milligrams of progesterone and around 100 milligrams of pregnenolone.
The Myths about Serotonin
Serotonin is not the 'happy hormone' but, rather, has significant implications in pathology. Previously known as 'in-terramine,' serotonin is linked to several issues, including depression, insomnia, and gut disorders. Many antidepressants and sleeping pills affect serotonin levels, but they come with potential toxicities. Treating depression and insomnia using GABA can be more effective and less harmful. GABA acts as an inhibitory neurotransmitter, and its agonists, like progesterone and pregnenolone, can provide relief from depression and insomnia and mitigate serotonin-related problems. Taking GABA and balancing hormonal levels offer safer alternatives to conventional medications.
The Importance of Hormone Balance and Hormone Modulation
Maintaining a balanced hormone system is crucial for overall health. Understanding the risks and benefits of specific hormones, such as estrogen, progesterone, and pregnenolone, can help guide effective hormone modulation strategies. Considering the impact of hormones on various conditions, including cancer, obesity, and mental health, highlights the importance of maintaining hormonal equilibrium throughout life. Progesterone and pregnenolone offer promising alternatives for hormone balance and modulation without the potential risks associated with conventional treatments.
GABA and Progesterone: Effective Solutions for Sleep and Mental Health
GABA, an amino acid, and progesterone, a GABA agonist, can be taken together to improve sleep quality and mental health. Oral GABA has been found to be bioavailable, contradicting previous beliefs, and even a low dose of 100 milligrams has shown to lower anxiety and depression scores. Combining GABA with another GABA agonist, L-E9, further enhances the effects. For individuals taking antidepressants, it is recommended to consider non-serotonergic drugs such as myanserin or tianeptin. In addition to GABA supplementation, progesterone can inhibit serotonin synthesis and increase its degradation, alleviating the negative effects of elevated serotonin levels. The dosages for GABA can range from 500 milligrams to 2 grams daily, with some individuals benefiting from higher doses. Overall, these supplements provide affordable and easily accessible solutions for sleep and mental health issues.
Serotonin and its Effects: Understanding the Downsides
Serotonin, primarily produced in the gut, has various negative effects when elevated. It inhibits GABA receptors, interferes with proper electron flow, and increases inflammation. Serotonin has been linked to insomnia and has been shown to destroy empathy, love, and wisdom. The serotonin hypothesis of depression is being questioned, and evidence suggests that serotonin primarily has a metabolic inhibitory role. Serotonin precursor tryptophan has been proven to be directly carcinogenic. Excessive serotonin levels are associated with fibrosis and even aggressive behavior in animals. Strategies involving GABA, progesterone, and maintaining a clean bowel can help regulate serotonin and mitigate its negative impact.
Nitric Oxide and Carbon Dioxide: Understanding their Roles
Both nitric oxide and carbon dioxide have significant physiological functions. Carbon dioxide is the preferred and safer vasodilator, preventing calcium build-up and promoting decalcification of soft tissues. Nitric oxide, although classified as a vasodilator, is toxic to living tissue and can damage respiratory enzymes. Nitric oxide levels rise as a response to a perceived deficiency of carbon dioxide. The activation of inducible nitric oxide synthesis occurs when carbon dioxide levels decline, resulting in vasodilation. High amounts of nitric oxide can lead to metabolic inhibition and the covalent binding of nitric oxide to cytochrome c oxidase, while nitric oxide production is also associated with antimicrobial activity. Controlling nitric oxide production and promoting adequate carbon dioxide levels are essential for optimal health and cardiovascular function.
In this interview Georgi Dinkov, a Bulgarian bioenergetic researcher, discusses the downsides of estrogen and serotonin, both of which are generally considered beneficial for physical and mental health.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
