Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition NAD+, NMN & Longevity: What the Science Really Says | Dr. Rupy Aujla | Be Well Moments
Oct 13, 2025
In this engaging discussion, Dr. Rupy Aujla, a medical doctor and nutrition expert, delves into NAD+ and NMN's role in longevity. He highlights the gap between promising animal studies and human evidence, urging a cautious approach. Rupy compares the effectiveness of oral supplements versus IV drips, questioning their nutrient delivery. He advocates for exercise and mental health over supplements for mitochondrial support. The conversation also explores potential cancer risks linked to excessive NAD+ and the dangers of high-dose nutrients disrupting balance.
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NAD+ Is Biologically Important But Evidence-Limited
- NAD+ (nicotinamide adenine dinucleotide) is a mitochondrial cofactor that declines with age and drives interest in longevity interventions.
- Most promising NAD+ effects come from animal studies and lack robust human trial evidence.
IV Delivery Bypasses Digestion But Not Unknown Biology
- IV NAD+ bypasses digestion but we still lack evidence it reaches mitochondria or works as claimed in humans.
- Cellular transport routes between bloodstream, cytoplasm and mitochondria remain poorly understood for NAD+ delivery.
Choose Exercise Over Experimental Drips
- Prioritise proven mitochondrial boosters like HIIT and zone 2 training over experimental NAD+ IVs or supplements.
- Consider cold exposure as an adjunct because it has more supportive evidence than NMN/NAD therapies.