The Science of Staying Young: Senolytics Explained by Dr. Gregory Kelly!
May 22, 2024
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Dr. Gregory Kelly discusses cellular senescence and senolytics in the Wild Health Podcast. Topics include the impact of senescent cells on health, evolution of senolytics, mechanisms of senolytics, practical insights on usage, and the creation of Qualia Senolytic supplement for enhanced wellness.
Cellular senescence leads to altered gene expression and damage accumulation, affecting aging progression.
Senolytics target and eliminate senescent cells, offering potential to improve tissue function and combat aging.
Deep dives
Understanding Cellular Senescence and its Impact on Aging
Cellular senescence occurs when cells can no longer divide and replace themselves due to profound cellular stress, leading to resistance to apoptosis. This process is considered a hallmark of aging, contributing to damage accumulation and altered gene expression as we age. Senescent cells secrete molecules into the environment, affecting nearby healthy cells and potentially accelerating aging.
Causes of Cellular Senescence
Cellular senescence can be caused by factors like replicative senescence, where cells reach a limit on divisions, and stress-induced senescence due to various stressors like poor nutrition, mitochondrial dysfunction, radiation, or toxins. Senescent cells resist apoptosis and can zombify nearby healthy cells by secreting unique molecules, leading to their accumulation over time.
Senolytics: Targeting Senescent Cells
Senolytics are compounds that induce senescent cells to undergo apoptosis, reducing their burden in tissues. These compounds work by targeting pathways that regulate cellular survival decisions, offering a potential intervention for combating aging-related tissue dysfunction. Different senolytics act through various mechanisms and may show tissue-specific effectiveness.
Qualia Senolytic and its Unique Composition
Qualia Senolytic is a supplement designed to target senescent cells and improve overall health by incorporating senolytic compounds like fisetin, Hyperlongamine, and luteolin. The formula aims to address senescence in a variety of tissues and organs, using an intermittent dosing approach to maximize effectiveness. Initial studies indicate improvements in joint health and overall well-being, highlighting the potential benefits of this innovative product.
In this episode of the Wild Health Podcast, Dr. Mike Mallin sits down with Dr. Gregory Kelly to explore the fascinating world of cellular senescence and senolytics. Cellular senescence, a state where cells cease to divide and function properly, is a critical aspect of aging. Dr. Kelly delves into the mechanisms behind senescence, the impact of senescent cells on our health, and the groundbreaking potential of senolytics—compounds designed to selectively target and eliminate these "zombie cells."
Join us as we cover:
The basics of cellular senescence and why it matters.
The dual theories of aging: programmed aging vs. damage accumulation.
The discovery and evolution of senolytics, from early genetic modifications in animals to the latest research on compounds like quercetin and fisetin.
The mechanisms by which senolytics work and their role in promoting cellular health.
Practical insights into how senolytics can be used, including the importance of dosage and the concept of "hit and run" dosing.
The story behind Neurohacker Collective’s Qualia Senolytic, a supplement designed to harness the power of senolytics for improved joint health, energy, and overall wellness.
Whether you're a health enthusiast or simply curious about the latest advancements in longevity science, this episode is packed with valuable information and actionable insights.
Tune in to learn how you can take control of your aging process and enhance your health span with the power of senolytics. Visit neurohacker.com/wildhealth and use the code wildhealth for 15% off Qualia Senolytic and other cutting-edge health products.
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