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The Science of Staying Young: Senolytics Explained by Dr. Gregory Kelly!

Wild Health Podcast

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The Evolution of Senolytics Research

This chapter traces the development of senolytics from early experiments to the discovery of compounds that induce apoptosis in senescent cells. It discusses the mechanisms of various senolytic compounds like Desatinib and plant polyphenols, emphasizing the role of nutrient sensing pathways and the distinctions between pharmaceutical drugs and natural compounds. The chapter explores dosing strategies, ongoing clinical trials, the effects on cellular metabolism, and the intermittent approach to using senolytics with insights into creating proportional changes for cell behavior.

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