Longevity by Design Do NAD Analogs and Resveratrol Boost Cellular Health and Longevity With Dr. Joe Baur
Jan 10, 2024
Dr. Joe Baur, a Professor at the Perelman School of Medicine, dives into the intriguing world of NAD+ and its connection to cellular health and longevity. He discusses how NAD+ levels decline with age, impacting metabolism and overall well-being. The benefits of resveratrol supplements for insulin sensitivity are explored, as well as strategies to combat declining NAD+ levels through natural interventions like exercise and dietary changes. Baur also sheds light on the complexities of NAD supplementation and the ongoing research into its potential for health optimization.
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Joe Baur Joins Sinclair Lab
- Joe Baur shared his experience joining David Sinclair's lab to test resveratrol in mice.
- They showed resveratrol fully prevented shortened lifespan caused by obesity in mice.
NAD+'s Vital Metabolic Role
- NAD+ is crucial for metabolism by accepting and donating electrons in energy production.
- Without NAD+, cells cannot sustainably generate ATP and thus cannot survive.
Diverse NAD-Dependent Enzymes
- Enzymes like sirtuins, PARPs, CD38, and SARM1 depend on NAD+ for activity.
- SARM1, linked to axonal degeneration, is a key emerging player in NAD metabolism and neurodegeneration.