#60: PUFA as a Mitochondrial Toxin | Vitamin D, Inflammation, and Aging | Iron, Copper, and Anemia with Georgi Dinkov
Jun 21, 2021
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Topics discussed include mitochondrial dysfunction causing anemia, serotonin synthesis linked to breast cancer, benefits of vitamin D in addiction treatment, PUFA deficiency reversing alcohol effects on mitochondria, and hypothetical scenarios of power and water outages.
Serotonin levels predict tissue aggression in cancer cells.
Vitamin B1 and B3 combination shows promise in cancer treatment.
Potential use of serotonin antagonists in Parkinson's disease treatment.
Deep dives
Serotonin Levels as a Predictor of Cancer Tissue Aggressiveness
Serotonin levels inside cancer cells were found to be a highly reliable predictor of tissue aggression, distinguishing normal tissue from cancerous or dysplastic tissue. Serotonin antagonists are being tested for their anti-cancer effects, with a focus on a drug used in China for COVID-19 treatment. The antagonists may inhibit the virus's ability to infect cells due to improvements in cellular energetics.
Vitamin B1 and B3 Combination for Cancer Treatment
Studies are being conducted on the combination of vitamin B1 and B3 for cancer treatment. Vitamin B1 acts as a cofactor for pyruvate dehydrogenase, enhancing glucose oxidation. The combination has shown promising results in making liver and pancreatic cancer disappear in animal studies, indicating potential therapeutic effects.
Synthesis of Serotonin Antagonists and their Therapeutic Potential
Research is underway on synthesizing serotonin antagonists for cancer treatment. Specific compounds such as tropoxin, a unique Russian drug similar to cyproheptadine, and 10-methoxy-Carman are being investigated for their anti-cancer effects. These compounds have shown promise in inhibiting cell entry of viruses, including SARS-CoV-2.
Issues with Methylsergide Use and Legal Concerns
Methylsergide, specifically 10-methoxy-Carman, came under scrutiny recently in France due to its use in illegal therapeutic trials. The compound, a serotonin antagonist with similarities to LSD, has shown potency in microgram amounts. Legal concerns arise due to potential regulatory restrictions on its use, despite being currently available for research purposes.
Impacts of Serotonin on Parkinson's Disease Treatment
Recent studies highlighted in the podcast suggest that symptoms of Parkinson's disease may be driven more by serotonin excess than dopamine deficiency. This revelation indicates a potential shift in treatment strategies for Parkinson's, with serotonin antagonists being considered as a viable solution. The discussion focused on a trial where a medical doctor's approach towards treating Parkinson's disease by targeting serotonin was acknowledged, shedding light on new perspectives for managing this condition.
Vitamin D's Role in Treating Opioid Addiction and Promoting Health
The podcast delved into the correlation between lower vitamin D levels and addiction, revealing that administering vitamin D could potentially help in treating addiction. This discussion highlighted the diverse benefits of vitamin D, ranging from addressing mental disorders to promoting energy production in muscles. Vitamin D's versatile functions, including its steroid properties and role in reducing aggression, were emphasized as key factors in supporting overall metabolic health and potentially mitigating addiction issues.
00:00 - Skip setup music, catching up with Georgi, Eric Schmidt, automation, A.I., depopulation
26:38 - Mitochondrial dysfunction may be the cause of anemia, iron, copper, ceruloplasmin, ferritin
37:15 - Upregulated serotonin synthesis may be a biomarker for breast cancer, lidocaine for digestion, olive oil
50:13 - Idealabs update
01:00:37 - Vitamin D may treat (opioid) “addiction," PTH, tryptophan hydroxylase, serotonin, pregnenolone, "post-finasteride syndrome"
01:13:02 - PUFA deficiency reverses effects of alcohol on mitochondrial energy metabolism, cardiolipin, cytochrome c oxidase, electron flow, nitric oxide
01:19:57 - Outro chat, hypothetical power and water outages
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