Using Fasting Strategies to Reduce Inflammaging and Longevity with Dr. Joseph Antoun

Aug 19, 2025

Dr. Joseph Antoun, CEO of L-Nutra Inc., focuses on food as medicine for longevity. He discusses how fasting, particularly fasting-mimicking diets, can rejuvenate immune cells and combat chronic inflammation, a key player in aging. The conversation highlights the detrimental effects of senescent cells and emphasizes the balance between cell growth and repair. Antoun explores practical fasting strategies to promote autophagy, and shares insights on integrating these methods for improved health and longevity, making the science of aging accessible and actionable.

Ask episode

AI Snips

Chapters

Transcript

Episode notes

INSIGHT

Senescent Cells Drive Inflammaging

Senescent "zombie" cells accumulate with age and secrete inflammatory factors that accelerate aging.
Clearing these cells reduces inflammaging and lowers risk for age-related diseases.

INSIGHT

Immune Aging Undermines Defense

Immunosenescence means the immune system itself ages and loses function while making mistakes.
This decline permits cancer, chronic infection, and autoimmune errors to emerge more easily.

INSIGHT

Daily Nutrition Shapes Biological Aging

Nutrition is a primary, daily input that shapes microbiome, epigenetics, and aging.
Small, repeated dietary choices cumulatively determine how we age and regenerate.

Get the Snipd Podcast app to discover more snips from this episode

Get the app

In this episode, Dr. Jockers sits down with Dr. Joseph Antoun to unpack how fasting strategies, including fasting-mimicking diets, can rejuvenate immune cells, slow down inflammaging, and support overall healthy aging.

You’ll discover how chronic inflammation accelerates aging, why old “zombie” cells cause damage, and how fasting helps clear them out while replacing them with stronger, more resilient ones. The conversation also dives into immunosenescence, what happens when immune cells age, and how this process links to conditions like cancer, cardiovascular disease, and autoimmune disorders.

Dr. Antoun also explains the delicate balance between growth and repair in the body—and why our modern eating patterns keep us stuck in constant growth mode. By leveraging targeted fasting protocols, we can push our bodies toward autophagy, boost cell repair, and open the door to a healthier, longer life.

In This Episode:

00:00 Introduction to Fasting and Cellular Rejuvenation

00:48 Guest Introduction: Dr. Joseph Antoun

04:25 Understanding Chronic Inflammation and Inflammaging

10:10 The Role of Nutrition in Aging and Immune Health

13:13 Fasting Mimicking Diet: Science and Benefits

23:32 Fasting and Autoimmune Diseases

24:35 The Role of Stomach Acid in Digestion

26:28 ProLon and Biological Age Reduction

30:15 ProLon for Diabetes and Chronic Conditions

32:06 How to Use ProLon Effectively

38:06 Current Research and Future Directions

40:49 The Importance of Fasting in Human Health

42:39 Conclusion and Final Thoughts

Looking for a clean, nutrient-packed snack? Paleo Valley’s Grass-Fed Meat Sticks are free from sugar, additives, and preservatives—just pure protein and healthy fats to keep cravings in check and support muscle and immune health. They come in delicious flavors like Original, Garlic Summer Sausage, and Teriyaki, and they’re even kid-approved. Try them today and get 15% off your order at paleovalley.com/jockers.

Think heartburn comes from too much stomach acid? Think again. Most digestive issues actually stem from too little stomach acid. That’s why I recommend Just Thrive Digestive Bitters—they naturally stimulate stomach acid, bile, and enzymes to improve digestion, reduce bloating, and boost nutrient absorption.Save 20% off your order with code JOCKERS at justthrivehealth.com.

"As we age, our immune cells become more sluggish, but fasting helps rejuvenate them, giving you a youthful immune response."

Subscribe to the podcast on:

Resources:

Get 15% off Paleovalley: paleovalley.com/jockers – Use code JOCKERS
Save 20% on Just Thrive: justthrivehealth.com – Use code JOCKERS

Connect with Dr. Joseph Antoun:

Website: https://www.glownaturalwellness.com/

Connect with Dr. Jockers:

Instagram – https://www.instagram.com/drjockers/
Facebook – https:/www.facebook.com/DrDavidJockers
YouTube – https://www.youtube.com/user/djockers
Website – https://drjockers.com/

If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/