JAMA Clinical Reviews Managing Adverse Effects of Obesity Medications
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Jul 29, 2025 In this engaging discussion, obesity expert Robert Kushner, a Professor at Northwestern University, delves into the challenges of managing adverse effects of obesity medications like semaglutide and tirzepatide. He explores gastrointestinal side effects such as nausea and diarrhea, offering practical strategies for dietary management. Kushner also emphasizes the importance of addressing hydration and dosage adjustments, while highlighting how resistance training and high-protein diets can protect muscle health during treatment. A must-listen for anyone navigating the world of obesity therapies!
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Incretin Medications' Unique Effectiveness
- Incretin medications mimic GLP-1 and GIP to suppress appetite effectively.
- These medications achieve unprecedented average weight loss of 15-20%.
Diet Counseling Mitigates Side Effects
- Counsel patients with dietary advice to reduce GI side effects like nausea.
- Recommend avoiding greasy foods, alcohol, and carbonated drinks and eating regularly.
Real-World Medication Discontinuation
- Real-world adherence to these obesity medications is lower than trial data suggest.
- Up to 50% may discontinue by one year, likely due to side effects and insurance issues.