All-In with Chamath, Jason, Sacks & Friedberg Bryan Johnson: The #1 Longevity Secret You Can Start Doing Today
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Oct 14, 2025 
Bryan Johnson, a serial entrepreneur focused on longevity and reversing biological aging, discusses groundbreaking insights into health. He showcases a balance test that links performance to biological age and reveals the importance of knowing the age of individual organs. Johnson emphasizes the critical role of sleep, pointing to resting heart rate as a vital biomarker. He offers practical steps to enhance sleep quality, arguing it's key to improved mood and productivity. His compelling message encourages listeners to prioritize wellbeing and sleep hygiene.
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Balance Test Demonstrates Biological Age
- Bryan Johnson leads a balance test to demonstrate biological age differences in an audience activity.
- He explains balance decline is a measurable sign of brain aging and shows how to roughly map seconds balanced to age ranges.
Measuring Every Organ's Age
- Bryan recounts measuring the biological age of many organs across his body as part of an experiment.
- He used those measurements to guide interventions and publicly benchmark his biomarkers as a health competition.
Lower Your Pre-Sleep Heart Rate
- Do measure your resting heart rate before sleep and aim to lower it about 10% over a month.
- Do finish eating roughly four hours before bed, stop screens an hour before bed, and establish a wind-down routine to reduce pre-sleep heart rate.