Want to biohack your biology with nature’s most powerful anti-aging compounds? In this episode, you’ll discover how medicinal mushrooms fuel neurogenesis, protect mitochondria, supercharge immunity, and even help save the planet’s pollinators. From sharper focus and deeper REM sleep to protecting DNA from oxidative stress, fungi are the ultimate biohacking tools for performance, resilience, and longevity.
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(Re-run) Host Dave Asprey sits down with legendary mycologist and author Paul Stamets and mushroom entrepreneur Julian Mitchell. Together, they uncover the science of fungi as medicine — how mushrooms repair nerves, fight viruses, act as prebiotics for your microbiome, and provide the ultimate anti-aging biohacks. You’ll also hear how fungi hold the key to saving pollinators, regenerating soil, and extending human longevity.
You’ll Learn:
• Which anti-aging compounds in mushrooms protect your mitochondria and DNA
• How lion’s mane stimulates nerve growth factor and improves memory, focus, and REM sleep
• Why oyster mushrooms may help fight flu viruses and reduce chronic inflammation
• How mushroom tinctures unlock more bioactive compounds than powders or capsules
• The surprising role fungi play in saving bees and restoring environmental balance
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Keywords: anti-aging mushrooms, Paul Stamets fungi, lion’s mane memory, mushroom tincture benefits, ergothionine mitochondrial protection, oyster mushroom flu prevention, reishi immune system, cordyceps endurance, turkey tail microbiome, medicinal mushroom research, fungi save the bees, chaga antioxidants, mushroom longevity biohack, mycelium networks, functional mushrooms anti-inflammatory, mushroom brain health, neurogenesis fungi, adaptogenic mushrooms, mushroom cooking bioavailability
• Lifecykel Mushroom Products - use code ‘DAVE20’ for 20% off: https://www.lifecykel.com/?rfsn=4497217.61b030&utm_source=refersion&utm_medium=affiliate&am…
• Paul Stamets’ Website: https://hostdefense.com/
Thank you to our sponsors!
• ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.
Resources:
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Timestamps:
• 0:00 — Trailer
• 0:47 — Intro
• 6:15 — Mushrooms vs. Algae
• 10:21 — Mushroom Safety & Microbiome
• 12:24 — Mushrooms as Medicine
• 14:43 — Psychedelics & Microdosing
• 16:26 — Kakadu Plum & Prebiotics
• 18:07 — Oyster Mushrooms & Cooking
• 21:35 — Mushrooms & Bees
• 25:59 — Lion’s Mane & Chaga
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The Human Upgrade: Biohacking for Longevity & Performance 
