Understanding Menopause & Dementia Risk in Women with Dr Sarah McKay

Aug 3, 2025

In this engaging discussion, neuroscientist Dr. Sarah McKay, an expert in brain health for women, dives into the prevalence of dementia and Alzheimer's, particularly affecting women. She explains hormonal fluctuations during perimenopause and their impacts on brain function and emotional stability. Dr. McKay also unpacks the latest findings on Hormone Replacement Therapy and its role in supporting women’s brain health. Throughout, she emphasizes the critical need for social engagement and education in maintaining cognitive well-being.

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INSIGHT

Why More Women Have Dementia

Women have higher dementia prevalence mainly because they live longer than men.
Men with dementia tend to die sooner, affecting observed prevalence ratios.

INSIGHT

Education Builds Cognitive Reserve

Higher education builds cognitive reserve that boosts brain resilience.
Cognitive reserve helps protect the brain against aging effects and dementia risk.

ADVICE

Engage Brain Through Social Activities

Challenge your brain with social, physical, and cognitively engaging activities.
Avoid passive brain training; social interaction is key for brain health.

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All content and media by Project 100 is created and published online for informational purposes only. It is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice.
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In Part 2 of my discussion with neuroscientist Dr Sarah McKay, we kick off by looking at the prevalence of dementia—particularly Alzheimer’s—in Australia, and why women are disproportionately affected.

We also dive into the physiological shifts that occur during perimenopause—specifically the hormonal fluctuations that can affect brain function, sleep, and emotional stability. Dr McKay shares what the latest science says about Hormone Replacement Therapy (HRT): where it helps, where it doesn’t, and how it fits into the broader picture of women’s brain health.

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