Refined Carbs Clog Your Arteries: High Triglycerides Worse Than LDL-Cholesterol
Aug 28, 2023
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This podcast explores the overlooked significance of triglycerides in relation to atherosclerosis and sudden death. It highlights the association between high triglycerides and poor outcomes in cardiovascular disease. The podcast discusses the formation of plaque in coronary vessels due to triglycerides and emphasizes the need for APOB and APOA1 measurements in a lipid panel. It explores the increased risk of cardiovascular disease associated with high triglyceride levels, particularly in non-fasted states. The podcast provides strategies to support metabolic health and lower triglyceride levels, including vitamin D supplementation, myoinositol, and berberine, and emphasizes the importance of avoiding processed foods and prioritizing protein.
High levels of triglycerides are associated with the formation of plaque in blood vessels, contributing to cardiovascular disease.
Non-fasted triglyceride levels are an important marker for assessing cardiovascular risk, and lifestyle interventions can help lower triglyceride levels.
Deep dives
The Connection Between Triglycerides and Cardiovascular Disease
Triglycerides have been ignored by the medical community for decades, with focus primarily on lowering total cholesterol and LDL cholesterol. However, high levels of triglycerides have been found to be linked with cardiovascular disease, atherosclerosis, and even sudden death. This biomarker, often disregarded by people, is affected by dietary choices and is independent of red meat and saturated fat consumption. Processed foods high in carbohydrates can significantly increase triglyceride levels, which are associated with poor cardiovascular outcomes.
Importance of Triglycerides as a Marker of Metabolic Health
Elevated triglyceride levels, along with remnant cholesterol lipoproteins, have been shown to be strong indicators of metabolic health and carvascular disease risk. Even in patients taking lipid-lowering medications, high triglyceride levels are associated with poor outcomes. Triglycerides promote inflammation, clotting cascades, and endothelial dysfunction, making them a significant factor in atherosclerosis development. Assessing and managing triglyceride levels is crucial for maintaining metabolic health and reducing the risk of carvascular disease.
The Significance of Non-Fasted Triglyceride Levels
Non-fasted triglyceride levels have been identified as an important marker for assessing carvascular risk. Studies have shown that elevated non-fasted triglyceride levels are associated with increased risk of myocardial infarction, ischemic heart disease, and atherosclerotic carvascular disease. Focusing only on fasted triglyceride levels can overlook the potential risk posed by post-meal triglyceride spikes. Lifestyle interventions, such as exercise and nutrition, are crucial for lowering triglyceride levels and improving overall metabolic health.
After years of intensive LDL-lowering therapies heart disease is still the leading cause of death, claiming over 600,000 lives annually in the USA alone. It's time to focus more on triglycerides and metabolic health.
01:45 LDL lowering drugs do not affect triglycerides. 03:41 Triglycerides and remnant cholesterol are associated with the formation of plaque in vessels throughout your body. 05:45 Total cholesterol minus HDL minus LDL helps you determine your remnant cholesterol. 11:20 Triglyceride rich lipoproteins promote inflammation and adhesion. 12:00 High triglycerides (fasted and non-fasted) are associated with higher risk of atherosclerotic cardiovascular disease. 14:40 Increased triglyceride concentration is associated with a 37% increased risk of cardiovascular disease.
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