The Funk'tional Nutrition Podcast

SIBO & IBS: The Latest Research & Testing Options with Dr. Mark Pimentel | Ep 181

Nov 16, 2021

Dr. Mark Pimentel, renowned gastroenterology expert and researcher, discusses the latest research on IBS and SIBO, including new testing options. Topics include leading causes of IBS, the overlap between IBS and SIBO, diagnosing these conditions with blood and breath tests, debunking widely accepted concepts about SIBO, and the limitations of the low-FODMAP diet. A must-listen for clinicians, practitioners, and anyone interested in gut health and research.

01:01:18

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Episode guests

Mark Pimentel

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Highlights

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Quick takeaways

Dr. Mark Pimentel's research has led to the discovery of new treatment options for IBS and SIBO, including the use of refaxamine and low-dose statin.

The introduction of the TrioSmart test, which measures hydrogen sulfide in addition to hydrogen and methane, has improved the diagnosis of SIBO.

Individualized treatment plans are essential for managing SIBO, and promising developments in research suggest potential new treatments.

Deep dives

The discovery of refaxamine as a treatment for IBS and SIBO

Dr. Mark Pimentel discovered refaxamine as a treatment for IBS and SIBO. He also developed the first blood test for IBS and described the association between IBS and bacterial overgrowth. He further uncovered the role of methanobrevibacter smithii in causing constipation and the use of low-dose statin as a treatment for methane. These findings have significantly advanced our understanding of these conditions and provided new treatment options.

Understanding Antibody Levels in Chronic IBS

01:51

Understanding the Connection between Antibodies, Gut Flow, and SIBO

02:02

The Relationship Between Methane and Hydrogen in Gut Organisms

02:08

Introduction

1min

Introduction to Dr. Mark Pimentel's Expertise in Gastroenterology and Research

4min

Dr. Mark Pimentel: Contributions to SIBO and IBS

3min

The Importance of Bridging the Gap between Research and Practical Application

20min

PPI Use and SIBO: Latest Research Findings

5min

Functional Fibers, Polyphenols, and Gut Balance

6min

Fluids, Testing, and Substrates: Exploring SIBO and IBS

18min

Reservations about the Low-FODMAP Diet

4min

We’ve got a special episode for you today. Erin sits down with Dr. Mark Pimentel, researcher, clinician, and cofounder of Gemelli Biotech™, to discuss the latest research on IBS, SIBO, and new testing options for people who have struggled with these conditions. This is definitely a higher level podcast interview, so this episode is great for clinicians, practitioners, anyone who loves to geek out on gut health and research, or anyone who’s been struggling with IBS or SIBO and looking for answers. Erin and Mark discuss leading causes of IBS, the overlap of IBS & SIBO, why patients are often being dismissed in other practices, how the blood tests and breath tests for diagnosing these conditions work, why the treatment strategies are nuanced, and much more.

What makes Dr. Mark Pimentel's insights noteworthy is he’s not just a researcher; he’s also a clinician, and it’s the process of taking that information and applying it to humans where we learn so much. This is an episode you’ll want to refer back to - share with someone who could use this information!

In this episode:

-Why today’s guest is particularly noteworthy [1:08]

-Why Mark Pimentel continues his research [8:42]

-What is the leading cause of IBS? [10:37]

-The value behind the ibs-smart™ blood test [13:32]

-Inferring antibody patterns in post-infectious IBS [16:23]

-New research that debunks two widely accepted concepts about SIBO [21:41]

-The overlap between post-infectious IBS and SIBO [23:26]

-New info on PPI (proton pump inhibitor) use and SIBO [27:45]

-The potential problem with akkermansia as a probiotic supplement & other single-organism treatments [30:43]

-How does Intermittent Fasting or fluid affect the migrating motor complex & should these strategies be considered for IBS? [37:28]

-Hydrogen sulfide and the trio-smart® breath test for SIBO [39:18]

-How treatment differs for hydrogen-dominant SIBO (SIBO-D), Intestinal Methanogen Overgrowth (IMO) & hydrogen sulfide SIBO (H2S SIBO) [45:25]

-Does constipation with H2S occur? [48:55]

-The various types of bacteria that produce hydrogen gas [51:02]

-The mechanism of action of lovastatin as future treatment for methane in constipation [53:26]

-Using prokinetics for low motility [55:35]

-Pimentel’s thoughts on the low FODMAP diet [56:56]

FOR OUR FULL LIST OF LINKS + RESOURCES, HEAD TO: https://www.erinholthealth.com/funktional-nutrition-podcast/2021/11/16/episode-181-sibo-amp-ibs-the-latest-research-amp-testing-options-with-dr-mark-pimentel

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The Funk'tional Nutrition Podcast

SIBO & IBS: The Latest Research & Testing Options with Dr. Mark Pimentel | Ep 181

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

The discovery of refaxamine as a treatment for IBS and SIBO

The importance and challenges of diagnosing SIBO

Differentiating between hydrogen sulfide, hydrogen-dominant, and methane-dominant SIBO

The limitations of the low-FODMAP diet

Promising directions in SIBO research and treatment

Understanding Antibody Levels in Chronic IBS

Understanding the Connection between Antibodies, Gut Flow, and SIBO

The Relationship Between Methane and Hydrogen in Gut Organisms

Remember Everything You Learn from Podcasts